diff --git a/diff.c b/diff.c
index 4acccd9d7e..f9e86bca04 100644
--- a/diff.c
+++ b/diff.c
@@ -4628,6 +4628,9 @@ void diff_setup_done(struct diff_options *options)
 	if (HAS_MULTI_BITS(options->pickaxe_opts & DIFF_PICKAXE_KINDS_MASK))
 		die(_("-G, -S and --find-object are mutually exclusive"));
 
+	if (HAS_MULTI_BITS(options->pickaxe_opts & DIFF_PICKAXE_KINDS_G_REGEX_MASK))
+		die(_("-G and --pickaxe-regex are mutually exclusive, use --pickaxe-regex with -S"));
+
 	/*
 	 * Most of the time we can say "there are changes"
 	 * only by checking if there are changed paths, but
diff --git a/diff.h b/diff.h
index c8f3faea8a..5e110d349b 100644
--- a/diff.h
+++ b/diff.h
@@ -556,6 +556,8 @@ int git_config_rename(const char *var, const char *value);
 #define DIFF_PICKAXE_KINDS_MASK (DIFF_PICKAXE_KIND_S | \
 				 DIFF_PICKAXE_KIND_G | \
 				 DIFF_PICKAXE_KIND_OBJFIND)
+#define DIFF_PICKAXE_KINDS_G_REGEX_MASK (DIFF_PICKAXE_KIND_G | \
+					 DIFF_PICKAXE_REGEX)
 
 #define DIFF_PICKAXE_IGNORE_CASE	32
 
diff --git a/t/t4209-log-pickaxe.sh b/t/t4209-log-pickaxe.sh
index 532bb875f0..772c6c1a7c 100755
--- a/t/t4209-log-pickaxe.sh
+++ b/t/t4209-log-pickaxe.sh
@@ -66,6 +66,11 @@ test_expect_success 'usage' '
 	grep "mutually exclusive" err
 '
 
+test_expect_success 'usage: --pickaxe-regex' '
+	test_expect_code 128 git log -Gregex --pickaxe-regex 2>err &&
+	grep "mutually exclusive" err
+'
+
 test_expect_success 'usage: --no-pickaxe-regex' '
 	cat >expect <<-\EOF &&
 	fatal: unrecognized argument: --no-pickaxe-regex